Human FAM111B activation kit by CRISPRa

SKU GA117763

FAM111B CRISPRa kit - CRISPR gene activation of human family with sequence similarity 111 member B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: FAM111B
• Locus ID: 374393
• Components:

  GA117763G1, FAM111B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA117763G2, FAM111B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA117763G3, FAM111B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001142703, NM_001142704, NM_198947
• UniProt ID: Q6SJ93
• Synonyms: CANP; POIKTMP
• Summary: This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]