Human SYT10 activation kit by CRISPRa

SKU GA117515

SYT10 CRISPRa kit - CRISPR gene activation of human synaptotagmin 10

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SYT10
• Locus ID: 341359
• Components:

  GA117515G1, SYT10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA117515G2, SYT10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA117515G3, SYT10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_198992
• UniProt ID: Q6XYQ8
• Synonyms: MGC119436; MGC119437
• Summary: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).[UniProtKB/Swiss-Prot Function]