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Human GSDMA activation kit by CRISPRa

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SKU
GA117097
GSDMA CRISPRa kit - CRISPR gene activation of human gasdermin A
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC219050 GSDMA (Myc-DDK-tagged)-Human gasdermin A (GSDMA)
10 ug
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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol GSDMA
Locus ID 284110
Components

GA117097G1, GSDMA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA117097G2, GSDMA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA117097G3, GSDMA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_178171
UniProt ID Q96QA5
Synonyms FKSG9; GSDM; GSDM1
Summary May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN419050 GSDMA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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