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Human Prune homolog 2 (PRUNE2) activation kit by CRISPRa

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SKU
GA115963
PRUNE2 CRISPRa kit - CRISPR gene activation of human prune homolog 2 with BCH domain
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA305724 Goat Anti-PRUNE2 / BMCC1 Antibody
100 ug
$565.00
RC205712 PRUNE2 (Myc-DDK-tagged)-Human prune homolog 2 (Drosophila) (PRUNE2), transcript variant 2
10 ug
$300.00

Other products for "PRUNE2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PRUNE2
Locus ID 158471
Components

GA115963G1, Prune homolog 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA115963G2, Prune homolog 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA115963G3, Prune homolog 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001308047, NM_001308048, NM_001308049, NM_001308050, NM_001308051, NM_001330680, NM_015225, NM_138818, NR_131751
UniProt ID Q8WUY3
Synonyms BMCC1; BNIPXL; C9orf65; KIAA0367
Summary The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN405712 PRUNE2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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