Human GRPEL2 activation kit by CRISPRa

SKU GA115220

GRPEL2 CRISPRa kit - CRISPR gene activation of human GrpE like 2, mitochondrial

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GRPEL2
• Locus ID: 134266
• Components:

  GA115220G1, GRPEL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115220G2, GRPEL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115220G3, GRPEL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_152407
• UniProt ID: Q8TAA5
• Synonyms: Mt-GrpE#2
• Summary: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).[UniProtKB/Swiss-Prot Function]