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Human JMY activation kit by CRISPRa

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SKU
GA115208
JMY CRISPRa kit - CRISPR gene activation of human junction mediating and regulatory protein, p53 cofactor
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA316106 Rabbit polyclonal anti-JMY antibody
100 ul
$380.00
RC229401 JMY (Myc-DDK-tagged)-Human junction mediating and regulatory protein, p53 cofactor (JMY)
10 ug
$905.00

Other products for "JMY"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol JMY
Locus ID 133746
Components

GA115208G1, JMY gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA115208G2, JMY gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA115208G3, JMY gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_152405
UniProt ID Q8N9B5
Synonyms WHAMM2; WHDC1L3
Summary Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN413595 JMY - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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