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Human OLFM2 activation kit by CRISPRa

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SKU
GA114268
OLFM2 CRISPRa kit - CRISPR gene activation of human olfactomedin 2
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC203786 OLFM2 (Myc-DDK-tagged)-Human olfactomedin 2 (OLFM2)
10 ug
$457.00

Other products for "OLFM2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol OLFM2
Locus ID 93145
Components

GA114268G1, OLFM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114268G2, OLFM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114268G3, OLFM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001304347, NM_001304348, NM_058164
UniProt ID O95897
Synonyms NOE2; NOELIN2; NOELIN2_V1; OlfC
Summary Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN403786 OLFM2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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