Human LSM10 activation kit by CRISPRa

SKU GA113807

LSM10 CRISPRa kit - CRISPR gene activation of human LSM10, U7 small nuclear RNA associated

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LSM10
• Locus ID: 84967
• Components:

  GA113807G1, LSM10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113807G2, LSM10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113807G3, LSM10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_032881
• UniProt ID: Q969L4
• Synonyms: MST074; MSTP074
• Summary: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.[UniProtKB/Swiss-Prot Function]