Human LRRC8C activation kit by CRISPRa

SKU GA113436

LRRC8C CRISPRa kit - CRISPR gene activation of human leucine rich repeat containing 8 VRAC subunit C

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LRRC8C
• Locus ID: 84230
• Components:

  GA113436G1, LRRC8C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113436G2, LRRC8C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113436G3, LRRC8C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_032270
• UniProt ID: Q8TDW0
• Synonyms: AD158; FAD158
• Summary: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.[UniProtKB/Swiss-Prot Function]