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Human CXXC4 activation kit by CRISPRa

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SKU
GA112920
CXXC4 CRISPRa kit - CRISPR gene activation of human CXXC finger protein 4
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA320030 Rabbit Polyclonal CXXC4 Antibody
100 ug
$640.00
RC212834 CXXC4 (Myc-DDK-tagged)-Human CXXC finger protein 4 (CXXC4)
10 ug
$300.00

Other products for "CXXC4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CXXC4
Locus ID 80319
Components

GA112920G1, CXXC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112920G2, CXXC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112920G3, CXXC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_025212, NR_132741
Synonyms IDAX
Summary This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN412834 CXXC4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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