Human CMG1 (IFT74) activation kit by CRISPRa

SKU GA112849

IFT74 CRISPRa kit - CRISPR gene activation of human intraflagellar transport 74

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: IFT74
• Locus ID: 80173
• Components:

  GA112849G1, CMG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112849G2, CMG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112849G3, CMG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001099222, NM_001099223, NM_001099224, NM_025103, NM_001349928
• UniProt ID: Q96LB3
• Synonyms: BBS20; CCDC2; CMG-1; CMG1
• Summary: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]