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Human BBS10 activation kit by CRISPRa

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SKU
GA112590
BBS10 CRISPRa kit - CRISPR gene activation of human Bardet-Biedl syndrome 10
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC205501 BBS10 (Myc-DDK-tagged)-Human Bardet-Biedl syndrome 10 (BBS10)
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Other products for "BBS10"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BBS10
Locus ID 79738
Components

GA112590G1, BBS10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112590G2, BBS10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112590G3, BBS10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_024685
UniProt ID Q8TAM1
Synonyms C12orf58
Summary This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. provided by RefSeq, Jan 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN405501 BBS10 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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