Human RASAL3 activation kit by CRISPRa

SKU GA112198

RASAL3 CRISPRa kit - CRISPR gene activation of human RAS protein activator like 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RASAL3
• Locus ID: 64926
• Components:

  GA112198G1, RASAL3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112198G2, RASAL3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112198G3, RASAL3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_022904, NM_001348027, NM_001348028
• UniProt ID: Q86YV0
• Synonyms: DKFZp667E013; FLJ00087; FLJ21438
• Summary: This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]