Human SNAP-beta (NAPB) activation kit by CRISPRa

SKU GA111910

NAPB CRISPRa kit - CRISPR gene activation of human NSF attachment protein beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NAPB
• Locus ID: 63908
• Components:

  GA111910G1, SNAP-beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111910G2, SNAP-beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111910G3, SNAP-beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001283018, NM_001283020, NM_001283026, NM_022080, NR_104266
• UniProt ID: Q9H115
• Synonyms: SNAP-BETA; SNAPB
• Summary: This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]