Human OVOL2 activation kit by CRISPRa

SKU GA111778

OVOL2 CRISPRa kit - CRISPR gene activation of human ovo like zinc finger 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: OVOL2
• Locus ID: 58495
• Components:

  GA111778G1, OVOL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111778G2, OVOL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111778G3, OVOL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001303461, NM_001303462, NM_021220
• UniProt ID: Q9BRP0
• Synonyms: EUROIMAGE566589; ZNF339
• Summary: This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]