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Human C3orf37 (HMCES) activation kit by CRISPRa

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SKU
GA111287
HMCES CRISPRa kit - CRISPR gene activation of human 5-hydroxymethylcytosine binding, ES cell specific
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA357368 HMCES Antibody - N-terminal region
100 ul
$585.00
RC208710 C3orf37 (Myc-DDK-tagged)-Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1
10 ug
$457.00

Other products for "HMCES"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HMCES
Locus ID 56941
Components

GA111287G1, C3orf37 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA111287G2, C3orf37 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA111287G3, C3orf37 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001006109, NM_020187, NM_001370343, NM_001370344, NM_001370345, NM_001363881
UniProt ID Q96FZ2
Synonyms C3orf37; DC12; SRAPD1
Summary Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (PubMed:30554877). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN408710 HMCES - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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