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Human PEN2 (PSENEN) activation kit by CRISPRa

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SKU
GA111019
PSENEN CRISPRa kit - CRISPR gene activation of human presenilin enhancer, gamma-secretase subunit
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA306368 Rabbit Polyclonal PEN2 Antibody
100 ug
$640.00
RC203272 PSENEN (Myc-DDK-tagged)-Human presenilin enhancer 2 homolog (C. elegans) (PSENEN)
10 ug
$150.00

Other products for "PSENEN"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PSENEN
Locus ID 55851
Components

GA111019G1, PEN2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA111019G2, PEN2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA111019G3, PEN2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001281532, NM_018468, NM_172341
UniProt ID Q9NZ42
Synonyms MDS033; MSTP064; PEN-2; PEN2
Summary Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2013
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Documents
Resources
Other Versions
SKU Description Size Price
KN403272 PSENEN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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