Human SCYL2 activation kit by CRISPRa

SKU GA110879

SCYL2 CRISPRa kit - CRISPR gene activation of human SCY1 like pseudokinase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SCYL2
• Locus ID: 55681
• Components:

  GA110879G1, SCYL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110879G2, SCYL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110879G3, SCYL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001317784, NM_001330253, NM_001330254, NM_001330256, NM_017988
• UniProt ID: Q6P3W7
• Synonyms: CVAK104
• Summary: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]