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Human DC SIGN (CD209) activation kit by CRISPRa

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SKU
GA109395
CD209 CRISPRa kit - CRISPR gene activation of human CD209 molecule
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC220486 CD209 (Myc-DDK-tagged)-Human CD209 molecule (CD209), transcript variant 1
10 ug
$457.00

Other products for "CD209"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CD209
Locus ID 30835
Components

GA109395G1, DC SIGN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109395G2, DC SIGN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109395G3, DC SIGN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001144893, NM_001144894, NM_001144895, NM_001144896, NM_001144897, NM_001144899, NM_021155, NR_026692
UniProt ID Q9NNX6
Synonyms CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
Summary This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. provided by RefSeq, May 2020
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Documents
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Other Versions
SKU Description Size Price
KN420486 CD209 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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