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Human PILRA activation kit by CRISPRa

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SKU
GA109364
PILRA CRISPRa kit - CRISPR gene activation of human paired immunoglobin like type 2 receptor alpha
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA341919 Rabbit Polyclonal Anti-PILRA Antibody
100 ul
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RC222662 PILRA (Myc-DDK-tagged)-Human paired immunoglobin-like type 2 receptor alpha (PILRA), transcript variant 1
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Other products for "PILRA"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PILRA
Locus ID 29992
Components

GA109364G1, PILRA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109364G2, PILRA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109364G3, PILRA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_013439, NM_178272, NM_178273
UniProt ID Q9UKJ1
Synonyms FDF03
Summary Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN420244 PILRA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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