Human PPP2R3B activation kit by CRISPRa

SKU GA109154

PPP2R3B CRISPRa kit - CRISPR gene activation of human protein phosphatase 2 regulatory subunit B''beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PPP2R3B
• Locus ID: 28227
• Components:

  GA109154G1, PPP2R3B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109154G2, PPP2R3B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109154G3, PPP2R3B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_013239, NM_199326
• UniProt ID: Q9Y5P8
• Synonyms: NYREN8; PPP2R3L; PPP2R3LY; PR48
• Summary: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]