Human Neurobeachin (NBEA) activation kit by CRISPRa

SKU GA108949

NBEA CRISPRa kit - CRISPR gene activation of human neurobeachin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NBEA
• Locus ID: 26960
• Components:

  GA108949G1, Neurobeachin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108949G2, Neurobeachin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108949G3, Neurobeachin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001204197, NM_015678
• UniProt ID: Q8NFP9
• Synonyms: BCL8B; LYST2
• Summary: This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]