Human ORC3L (ORC3) activation kit by CRISPRa

SKU GA108423

ORC3 CRISPRa kit - CRISPR gene activation of human origin recognition complex subunit 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ORC3
• Locus ID: 23595
• Components:

  GA108423G1, ORC3L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108423G2, ORC3L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108423G3, ORC3L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001197259, NM_012381, NM_181837
• UniProt ID: Q9UBD5
• Synonyms: LAT; LATHEO; ORC3L
• Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]