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Human RFTN1 activation kit by CRISPRa

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SKU
GA108102
RFTN1 CRISPRa kit - CRISPR gene activation of human raftlin, lipid raft linker 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC223383L3V Lenti ORF particles, RFTN1 (Myc-DDK tagged) - Human raftlin, lipid raft linker 1 (RFTN1), 200ul, >10^7 TU/mL
200 ul
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Other products for "RFTN1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RFTN1
Locus ID 23180
Components

GA108102G1, RFTN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108102G2, RFTN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108102G3, RFTN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_015150
UniProt ID Q14699
Synonyms MIG2; PIB10; PIG9; RAFTLIN
Summary Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN423383 RFTN1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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