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Human CD299 (CLEC4M) activation kit by CRISPRa

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SKU
GA107044
CLEC4M CRISPRa kit - CRISPR gene activation of human C-type lectin domain family 4 member M
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC207947 CLEC4M (Myc-DDK-tagged)-Human C-type lectin domain family 4, member M (CLEC4M), transcript variant 1
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Other products for "CLEC4M"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CLEC4M
Locus ID 10332
Components

GA107044G1, CD299 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107044G2, CD299 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107044G3, CD299 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001144904, NM_001144905, NM_001144906, NM_001144907, NM_001144908, NM_001144909, NM_001144910, NM_001144911, NM_014257, NM_214675, NM_214676, NM_214677, NM_214678, NM_214679, NR_026707, NR_026708, NR_026709
UniProt ID Q9H2X3
Synonyms CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
Summary This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. provided by RefSeq, May 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN407947 CLEC4M - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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