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Human GLCNE (GNE) activation kit by CRISPRa

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SKU
GA106788
GNE CRISPRa kit - CRISPR gene activation of human glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC222626 GNE (Myc-DDK-tagged)-Human glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE), transcript variant 2
10 ug
$661.00

Other products for "GNE"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol GNE
Locus ID 10020
Components

GA106788G1, GLCNE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106788G2, GLCNE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106788G3, GLCNE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001128227, NM_001190383, NM_001190384, NM_001190388, NM_005476
UniProt ID Q9Y223
Synonyms DMRV; GLCNE; IBM2; NM; Uae1
Summary The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN422626 GNE - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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