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Human SMG7 activation kit by CRISPRa

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SKU
GA106675
SMG7 CRISPRa kit - CRISPR gene activation of human SMG7 nonsense mediated mRNA decay factor
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC230659 SMG7 (Myc-DDK-tagged)-Human Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG7), transcript variant 5
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Other products for "SMG7"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SMG7
Locus ID 9887
Components

GA106675G1, SMG7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106675G2, SMG7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106675G3, SMG7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001174061, NM_014837, NM_173156, NM_201568, NM_201569, NM_001331007, NM_001350219, NM_001350220, NM_001350221, NM_001350222
UniProt ID Q92540
Synonyms C1orf16; EST1C; SGA56M
Summary This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Aug 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN412486 SMG7 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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