Human MRPP3 (KIAA0391) activation kit by CRISPRa

SKU GA106503

PRORP CRISPRa kit - CRISPR gene activation of human protein only RNase P catalytic subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRORP
• Locus ID: 9692
• Components:

  GA106503G1, MRPP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106503G2, MRPP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106503G3, MRPP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001256678, NM_001256679, NM_001256680, NM_001256681, NM_014672
• UniProt ID: O15091
• Synonyms: MRPP3; PRORP
• Summary: Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).[UniProtKB/Swiss-Prot Function]