Human NRG2 activation kit by CRISPRa

SKU GA106386

NRG2 CRISPRa kit - CRISPR gene activation of human neuregulin 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NRG2
• Locus ID: 9542
• Components:

  GA106386G1, NRG2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106386G2, NRG2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106386G3, NRG2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001184935, NM_004883, NM_013981, NM_013982, NM_013983, NM_013984, NM_013985
• UniProt ID: O14511
• Synonyms: DON1; HRG2; NTAK
• Summary: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]