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Human p35 (CDK5R1) activation kit by CRISPRa

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SKU
GA105890
CDK5R1 CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase 5 regulatory subunit 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA314819 Rabbit polyclonal anti-CDK5R1 antibody
100 ul
$380.00
RC206302 CDK5R1 (Myc-DDK-tagged)-Human cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1)
10 ug
$450.00

Other products for "CDK5R1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CDK5R1
Locus ID 8851
Components

GA105890G1, p35 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105890G2, p35 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105890G3, p35 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_003885
UniProt ID Q15078
Synonyms CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a
Summary The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN406302 CDK5R1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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