Human ABCB11 activation kit by CRISPRa

SKU GA105730

ABCB11 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily B member 11

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ABCB11
• Locus ID: 8647
• Components:

  GA105730G1, ABCB11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105730G2, ABCB11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105730G3, ABCB11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003742
• UniProt ID: O95342
• Synonyms: ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]