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Human Cullin 2 (CUL2) activation kit by CRISPRa

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SKU
GA105585
CUL2 CRISPRa kit - CRISPR gene activation of human cullin 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA314751 Rabbit polyclonal anti-Cullin 2 antibody
100 ul
$380.00
RC203304 CUL2 (Myc-DDK-tagged)-Human cullin 2 (CUL2), transcript variant 3
10 ug
$1,023.00

Other products for "CUL2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CUL2
Locus ID 8453
Components

GA105585G1, Cullin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105585G2, Cullin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105585G3, Cullin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001198777, NM_001198778, NM_001198779, NM_001324375, NM_001324376, NM_003591
UniProt ID Q13617
Synonyms MGC131970
Summary Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN403304 CUL2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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