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Human SMC1 (SMC1A) activation kit by CRISPRa

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SKU
GA105456
SMC1A CRISPRa kit - CRISPR gene activation of human structural maintenance of chromosomes 1A
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "SMC1A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SMC1A
Locus ID 8243
Components

GA105456G1, SMC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105456G2, SMC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105456G3, SMC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001281463, NM_006306
UniProt ID Q14683
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB
Summary Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Jul 2013
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Other Versions
SKU Description Size Price
KN415888 SMC1A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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