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Human TNFRSF1B activation kit by CRISPRa

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SKU
GA104925
TNFRSF1B CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 1B
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC208641 TNFRSF1B (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)
10 ug
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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TNFRSF1B
Locus ID 7133
Components

GA104925G1, TNFRSF1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104925G2, TNFRSF1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104925G3, TNFRSF1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001066
UniProt ID P20333
Synonyms CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN408641 TNFRSF1B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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