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Human SHC (SHC1) activation kit by CRISPRa

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SKU
GA104400
SHC1 CRISPRa kit - CRISPR gene activation of human SHC adaptor protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA501056 Anti-SHC1 (SHC) mouse monoclonal antibody, clone OTI3A1 (formerly 3A1) 100 ul
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Other products for "SHC1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SHC1
Locus ID 6464
Components

GA104400G1, SHC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104400G2, SHC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104400G3, SHC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001130040, NM_001130041, NM_001202859, NM_003029, NM_183001
UniProt ID P29353
Synonyms SHC; SHCA
Summary This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Feb 2011
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Other Versions
SKU Description Size Price
KN404362 SHC1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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