Human RRM2 activation kit by CRISPRa

SKU GA104231

RRM2 CRISPRa kit - CRISPR gene activation of human ribonucleotide reductase regulatory subunit M2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RRM2
• Locus ID: 6241
• Components:

  GA104231G1, RRM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104231G2, RRM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104231G3, RRM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001034, NM_001165931
• UniProt ID: P31350
• Synonyms: R2; RR2; RR2M
• Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]