Human PTPRN activation kit by CRISPRa

SKU GA103942

PTPRN CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type N

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PTPRN
• Locus ID: 5798
• Components:

  GA103942G1, PTPRN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103942G2, PTPRN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103942G3, PTPRN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001199763, NM_001199764, NM_002846
• UniProt ID: Q16849
• Synonyms: IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]