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Human PTBP1 activation kit by CRISPRa

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SKU
GA103891
PTBP1 CRISPRa kit - CRISPR gene activation of human polypyrimidine tract binding protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC201779 PTBP1 (Myc-DDK-tagged)-Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1
10 ug
$519.00

Other products for "PTBP1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PTBP1
Locus ID 5725
Components

GA103891G1, PTBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103891G2, PTBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103891G3, PTBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_002819, NM_031990, NM_031991, NM_175847
UniProt ID P26599
Synonyms HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN401779 PTBP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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