Human PNMT activation kit by CRISPRa

SKU GA103639

PNMT CRISPRa kit - CRISPR gene activation of human phenylethanolamine N-methyltransferase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PNMT
• Locus ID: 5409
• Components:

  GA103639G1, PNMT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103639G2, PNMT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103639G3, PNMT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002686, NR_073461
• UniProt ID: P11086
• Synonyms: PENT; PNMTase
• Summary: The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]