Human PMS1 activation kit by CRISPRa

SKU GA103631

PMS1 CRISPRa kit - CRISPR gene activation of human PMS1 homolog 1, mismatch repair system component

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PMS1
• Locus ID: 5378
• Components:

  GA103631G1, PMS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103631G2, PMS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103631G3, PMS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000534, NM_001128143, NM_001128144, NM_001289408, NM_001289409, NR_110332, NM_001321044, NM_001321045, NM_001321046, NM_001321047, NM_001321048, NM_001321049, NM_001321051
• UniProt ID: P54277
• Synonyms: HNPCC3; hPMS1; MLH2; PMSL1
• Summary: This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]