Human Nociceptin (PNOC) activation kit by CRISPRa

SKU GA103625

PNOC CRISPRa kit - CRISPR gene activation of human prepronociceptin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PNOC
• Locus ID: 5368
• Components:

  GA103625G1, Nociceptin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103625G2, Nociceptin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103625G3, Nociceptin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001284244, NM_006228
• UniProt ID: Q13519
• Synonyms: PPNOC
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]