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Human Phospholipase A2 IIA (PLA2G2A) activation kit by CRISPRa

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SKU
GA103581
PLA2G2A CRISPRa kit - CRISPR gene activation of human phospholipase A2 group IIA
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA808040 PLA2G2A mouse monoclonal antibody, clone OTI1C2 (formerly 1C2) 100 ul
$447.00
RC203250 PLA2G2A (Myc-DDK-tagged)-Human phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A), transcript variant 1
10 ug
$150.00

Other products for "PLA2G2A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PLA2G2A
Locus ID 5320
Components

GA103581G1, Phospholipase A2 IIA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103581G2, Phospholipase A2 IIA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103581G3, Phospholipase A2 IIA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000300, NM_001161727, NM_001161728, NM_001161729
UniProt ID P14555
Synonyms MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Summary The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.provided by RefSeq, Sep 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN403250 PLA2G2A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells
Dong, Meller, Succop et al
Int J Oncol (2014) 45 (3), 978-84 DOI: 10.3892/ijo.2014.2486
Cited by 35
AI Summary: OriGene products, specifically the human PLA2G2A cDNA clone (RC204307) and sPLA2-IIa antibody (TA328636), were used in this study to overexpress and detect sPLA2-IIa, respectively, enabling the authors to investigate its role in upregulating HER/HER2 signaling in lung cancer cells.
FigureFigureFigure
Showing 1-1 of 1 papers.
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