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Human MEKK3 (MAP3K3) activation kit by CRISPRa

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SKU
GA102872
MAP3K3 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 3
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA378267 MEKK3 Rabbit polyclonal Antibody
100 ul
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RC210317 MAP3K3 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 3 (MAP3K3), transcript variant 2
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Other products for "MAP3K3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol MAP3K3
Locus ID 4215
Components

GA102872G1, MEKK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102872G2, MEKK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102872G3, MEKK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001330431, NM_002401, NM_203351, NM_001363768
UniProt ID Q99759
Synonyms MAPKKK3; MEKK3
Summary This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN410317 MAP3K3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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