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Human SMAD2 activation kit by CRISPRa

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SKU
GA102775
SMAD2 CRISPRa kit - CRISPR gene activation of human SMAD family member 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC204604 SMAD2 (Myc-DDK-tagged)-Human SMAD family member 2 (SMAD2), transcript variant 1
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Other products for "SMAD2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SMAD2
Locus ID 4087
Components

GA102775G1, SMAD2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102775G2, SMAD2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102775G3, SMAD2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001003652, NM_001135937, NM_005901
UniProt ID Q15796
Synonyms hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2
Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. provided by RefSeq, May 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN404604 SMAD2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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