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Human HLA-DRB5 activation kit by CRISPRa

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SKU
GA102136
HLA-DRB5 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class II, DR beta 5
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA812174 HLA mouse monoclonal antibody,clone OTI4G7 100 ul
$447.00
RC203646 HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DR beta 5 (HLA-DRB5)
10 ug
$300.00

Other products for "HLA-DRB5"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HLA-DRB5
Locus ID 3127
Components

GA102136G1, HLA-DRB5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102136G2, HLA-DRB5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102136G3, HLA-DRB5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_002125
UniProt ID Q30154
Summary HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. provided by RefSeq, Feb 2020
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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