Human GABRE activation kit by CRISPRa

SKU GA101707

GABRE CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor epsilon subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GABRE
• Locus ID: 2564
• Components:

  GA101707G1, GABRE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101707G2, GABRE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101707G3, GABRE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004961, NM_021984, NM_021987, NM_021990
• UniProt ID: P78334
• Synonyms: GABA(A) receptor; gamma-aminobutyric acid (GABA) A receptor, epsilon; OTTHUMP00000025892
• Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]