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Human Neutrophil Elastase (ELANE) activation kit by CRISPRa

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SKU
GA101377
ELANE CRISPRa kit - CRISPR gene activation of human elastase, neutrophil expressed
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA368228 ELANE rabbit polyclonal antibody
100 ul
$310.00
RC210399 ELANE (Myc-DDK-tagged)-Human elastase, neutrophil expressed (ELANE)
10 ug
$300.00

Other products for "ELANE"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ELANE
Locus ID 1991
Components

GA101377G1, Neutrophil Elastase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101377G2, Neutrophil Elastase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101377G3, Neutrophil Elastase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001972
UniProt ID P08246
Synonyms ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
Summary Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. provided by RefSeq, Jan 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN410399 ELANE - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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