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Human Doublecortin (DCX) activation kit by CRISPRa

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SKU
GA101156
DCX CRISPRa kit - CRISPR gene activation of human doublecortin
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "DCX"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DCX
Locus ID 1641
Components

GA101156G1, Doublecortin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101156G2, Doublecortin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101156G3, Doublecortin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000555, NM_001195553, NM_178151, NM_178152, NM_178153, NM_001369374, NM_001369370, NM_001369371, NM_001369372, NM_001369373
UniProt ID O43602
Synonyms DBCN; DC; LISX; SCLH; XLIS
Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Sep 2010
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Other Versions
SKU Description Size Price
KN406454 DCX - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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