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Human Cyclin D2 (CCND2) activation kit by CRISPRa

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SKU
GA100627
CCND2 CRISPRa kit - CRISPR gene activation of human cyclin D2
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC210316 CCND2 (Myc-DDK-tagged)-Human cyclin D2 (CCND2)
10 ug
$450.00

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CCND2
Locus ID 894
Components

GA100627G1, Cyclin D2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100627G2, Cyclin D2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100627G3, Cyclin D2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001759
UniProt ID P30279
Synonyms KIAK0002; MPPH3
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). provided by RefSeq, Sep 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN410316 CCND2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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