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Human Complement C5 (C5) activation kit by CRISPRa

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SKU
GA100505
C5 CRISPRa kit - CRISPR gene activation of human complement C5
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA308856 Rabbit Polyclonal antibody to C5 (complement component 5)
100 ul
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RC218821 C5 (Myc-DDK-tagged)-Human complement component 5 (C5)
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Other products for "C5"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol C5
Locus ID 727
Components

GA100505G1, Complement C5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100505G2, Complement C5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100505G3, Complement C5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001317163, NM_001317164, NM_001735
UniProt ID P01031
Synonyms C5a; C5b; C5D; CPAMD4; ECLZB
Summary This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. provided by RefSeq, Nov 2015
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Other Versions
SKU Description Size Price
KN418821 C5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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